Lag Analysis of Genetic Networks in the Cell Cycle of Budding Yeast
نویسندگان
چکیده
The recent emergence of whole-genome expression data requires a novel computational method to efficiently extract biological information from the large-scale data. The typical method for extracting information about genetic networks is cluster analysis and Fourier analysis of gene-expression patterns [2, 3, 4]. These analyses have uncovered some of the genetic networks. However, in order to comprehend all of the genetic networks in a variety of biological processes, it is necessary to develop computational methods from various viewpoints. Here we propose a computational time-series analysis to infer gene-regulatory networks from whole-genome expression data.
منابع مشابه
Dynamical Analysis of Yeast Cell Cycle Using a Stochastic Markov Model
Introduction: The cell cycle network is responsible of control, growth and proliferation of cells. The relationship between the cell cycle network and cancer emergence, and the complex reciprocal interactions between genes/proteins calls for computational models to analyze this regulatory network. Ample experimental data confirm the existence of random behaviors in the interactions between gene...
متن کاملDynamical Analysis of Yeast Cell Cycle Using a Stochastic Markov Model
Introduction: The cell cycle network is responsible of control, growth and proliferation of cells. The relationship between the cell cycle network and cancer emergence, and the complex reciprocal interactions between genes/proteins calls for computational models to analyze this regulatory network. Ample experimental data confirm the existence of random behaviors in the interactions between gene...
متن کاملCell Timer/Cell Clock
Like the biological clock in the body, replication of each cell type (even different cells of the same organism) follows a timing program. Abnormal function of this timer could be an alarm for a disease like cancer. DNA replication starts from a specific point on the chromosome that is called the origin of replication. In contrast to prokaryotes in which DNA replication starts from a single ...
متن کاملIntegrative analysis of cell cycle control in budding yeast.
The adaptive responses of a living cell to internal and external signals are controlled by networks of proteins whose interactions are so complex that the functional integration of the network cannot be comprehended by intuitive reasoning alone. Mathematical modeling, based on biochemical rate equations, provides a rigorous and reliable tool for unraveling the complexities of molecular regulato...
متن کاملGenetic networks inducing invasive growth in Saccharomyces cerevisiae identified through systematic genome-wide overexpression.
The budding yeast Saccharomyces cerevisiae can respond to nutritional and environmental stress by implementing a morphogenetic program wherein cells elongate and interconnect, forming pseudohyphal filaments. This growth transition has been studied extensively as a model signaling system with similarity to processes of hyphal development that are linked with virulence in related fungal pathogens...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2001